Publications

Peer-reviewed Journal articles

1. H. Rhodius-Meester, M. Benedictus, M. Wattjes, F. Barkhof, P. Scheltens, M. Muller, W. van der Flier. MRI visual ratings of brain atrophy and white matter hyperintensities across the spectrum of cognitive decline are differently affected by age and diagnosis. Frontiers in Aging Neuroscience 9: 117, 2017.

2. T. Tong, C. Ledig, R. Guerrero, A. Schuh, J. Koikkalainen, A. Tolonen. H. Rhodius-Meester, F. Barkhof, B. Tijms, A. W. Lemstra, H. Soininen, A. M. Remes, G. Waldemar, S. Hasselbalch, P. Mecocci, M. Baroni, J. Lötjönen, W. van der Flier, D. Rueckert. Five-class differential diagnostics of neurodegenerative diseases using random undersampling boosting. NeuroImage Clinical 15: 613-624, 2017.

3. A. Luikku, A. Hall, O. Nerg, A. Koivisto, M. Hiltunen, S. Helisalmi, S-K. Herukka, A. Sutela, M. Kojoukhova, J. Mattila, J. Lötjönen, J. Rummukainen, I. Alafuzoff, J. Jääskeläinen, A. Remes, H. Soininen and V. Leinonen. Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus. Acta Neurochir 158(12): 2311-2319, 2016.

4. Miguel Ángel Muñoz-Ruiz, Anette Hall, Jussi Mattila, Juha Koikkalainen, Sanna-Kaisa Herukka, Minna Husso, Tuomo Hänninen, Ritva Vanninen, Yawu Liu, Merja Hallikainen, Jyrki Lötjönen, Hilkka Soininen and Päivi Hartikainen. Using the Disease State Fingerprint for differential diagnosis of frontotemporal degeneration and Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders 6: 313-329, 2016.

5. J. Koikkalainen, H. Rhodius-Meester, A. Tolonen, F. Barkhof, B. Tijms, AW. Lemstra, T. Tong, R. Guerrero, A. Schuh, C. Ledig, D. Rueckert, H. Soininen, AM. Remes, G. Waldemar, S. Hasselbalch, P. Mecocci, W. van der Flier and J. Lötjönen. Differential diagnosis of neurodegenerative diseases using structural MRI data. NeuroImage Clinical 11: 435-339, 2016.

6. H. Rhodius-Meester, J. Koikkalainen, J. Mattila, C. Teunissen, F. Barkhof, A. Lemstra, P. Scheltens, J. Löjtönen and W. van der Flier. Integrating biomarkers for underlying Alzhiemer’s disease in mild cognitive impairment in daily practice: Comparison of a clinical decision support system with individual biomarkers. Journal of Alzheimer’s Disease 50: 261-270, 2016.

7. A. Hall, J. Mattila, J. Koikkalainen, J. Lötjönen, R. Wolz, P. Scheltens, G. Frisoni, M. Tsolaki, F. Nobili, Y. Freund-Levi, L. Minthon, L. Frölich, H. Hampel, P. J. Visser and H. Soininen. Predicting Progression from Cognitive Impairment to Alzheimer’s Disease with the Disease State Index. Current Alzheimer Research, 12: 69-79, 2015.

Peer Reviewed Conferences & Workshops

1. J. Lötjönen, A. Tolonen, H. Rhodius-Meester, M. Bruun, J. Koikkalainen, F. Barkhof, B. Tijms, A. Lemstra, C. Teunissen, T. Tong, R. Guerrero, A. Schuh, C. Ledig, M. Baroni, D. Rueckert, H. Soininen, A. Remes, G. Waldemar, S. Hasselbalch, P. Mecocci and W. van der Flier. Towards data-driven medicine in differential diagnostics of neurodegenerative diseases. Alzheimer & Dementia 12(7): Supplement, P355, 2016. http://dx.doi.org/10.1016/j.jalz.2016.06.657

2. W. van der Flier, H. Pölönen, J. Koikkalainen, A. Tolonen, H. Rhodius-Meester, B. Tijms, A. Lemstra, F. Barkhof, T. Koene, C. Teunissen, D. Rueckert, H. Soininen, A. Remes, G. Waldemar, S. Hasselbalch, P. Mecocci, J. Lötjönen. Cost-efficient differential diagnostics of neurodegenerative diseases using a stratified approach. Alzheimer & Dementia 12(7): Supplement, P369-470, 2016. http://dx.doi.org/10.1016/j.jalz.2016.06.922

3. C. Bowles, C. Qin, C. Ledig, R. Guerrero, A. Hammers, R. Gunn, E. Sakka, D. Dickie, M. Hernández, N. Royle, J. Wallrdlaw. H. Rhodius-Meester, B. Tijms, A. Lemstra, W. van der Flier, F. Barkhof, P. Scheltens and D. Rueckert. Pseudo-Healthy Image Synthesis for White Matter Lesion Segmentation. International Workshop on Simulation and Synthesis in Medical Imaging (SASHIMI): 87-96, 2016.

4. C. Qin, R. Guerrero, C. Ledig, C. Bowles, P. Scheltens, F. Barkhof, H. Rhodius-Meester, B. Tijms, A. Lemstra, W. van der Flier, B. Glocker and D. Rueckert. A Semi-supervised Outlier Detection Algorithm for White Matter Hyperintensity Segmentation. Machine Learning in Medical Imaging: 7th International Workshop (MLMI), pp. 104-112, 2016.

5. C. Ledig, S. Kaltwang, A. Tolonen. J. Koikkalainen, P. Scheltens, F. Barkhof, H. Rhodius-Meester, B. Tijms, A. Lemstra, W. van der Flier J. Lötjönen and D. Rueckert. Differential dementia diagnosis on incomplete data with Latent Trees, Medical Image Computing and Computer-Assisted Intervention, MICCAI-2016: 44-52, 2016.

6. H. Rhodius-Meester, J. Koikkalainen, J. Mattila, J. Lötjönen, C. Teunissen, F. Barkhof, T. Koene, AW. Lemstra, P. Scheltens and W. van der Flier. Assessing underlying Alzheimers’s disease pathology in MCI patients from the Amsterdam Dementia Cohort by use of the PredictAD software tool. Alzheimer & Dementia 11(7): Supplement, P254-255, 2015. http://dx.doi.org/10.1016/j.jalz.2015.07.316

7. M. Bruun, K. Frederiksen, G. Waldemar, H. Soininen, W. van der Flier, P. Mecocci, H. Rhodius-Meester, S-K. Herukka, M. Baroni, A. Remes, T. Urhemaa, J. Mattila, J. Lötjönen and S. Hasselbalch. A prospective validation study of the PredictND tool – a diagnostic decision support tool: Rationale and design of the study. Alzheimer & Dementia 11(7): Supplement, P408, 2015. http://dx.doi.org/10.1016/j.jalz.2015.06.365

8. L. Chen, T. Tong, C. P. Ho, R. Patel, D. Cohen, A. C. Dawson, O. Halse, O. Geraghty, P. E. M. Rinne, C. J. White, T. Nakornchai, P. Bentley and D. Rueckert: Identification of Cerebral Small Vessel Disease Using Multiple Instance Learning. MICCAI (1) 2015: 523-530

9. C. Ledig, R. Guerrero, T. Tong, K. Gray, A. Schmidt-Richberg, A. Makropoulos, R. A. Heckemann, and D. Rueckert, Alzheimer's disease state classification using structural volumetry, cortical thickness and intensity features, MICCAI workshop Challenge on Computer-Aided Diagnosis of Dementia based on structural MRI data, pp. 55-64, 2014

Abstracts

1. S. Mahdiani, M. Bruun, M. Baroni, H. Rhodius-Meester, A. Lemstra, S-K. Herukka, M. Pikkarainen, T. Hänninen, M. van Gils, S. Hasselbalch, P. Mecocci, W. van der Flier, A. Remes, H. Soininen and J. Lötjönen. Detection of cognitive disorders using web-based cognitive games – validation against traditional methods. 27th Alzheimer Europe Conference, October 2-4, Berlin, Germany, 2017, accepted.

2. S. Mahdiani, T. Paajanen, M. Bruun, M. Baroni, H. Rhodius-Meester, A. Lemstra, S-K. Herukka, M. Pikkarainen, T. Hänninen, T. Ngandu, M. Kivipelto, M. van Gils, S. Hasselbalch, P. Mecocci, W. van der Flier, A. Remes, H. Soininen and J. Lötjönen. Detection of cognitive disorders using web-based cognitive test battery - validation against traditional methods. 27th Alzheimer Europe Conference, October 2-4, Berlin, Germany, 2017, accepted.

3. J. Pärkkä, S. Mahdiani, M. Bruun. M. Baroni, H. Rhodius-Meester, S-K. Herukka, M. van Gils, S. Hasselbalch, P. Mecocci, W. van der Flier, A. Remes, H. Soininen and J. Lötjönen. Gait as predictor of dementia risk. 27th Alzheimer Europe Conference, October 2-4, Berlin, Germany, 2017, accepted.

4. M. Bruun, L. Gjerum, K. Frederiksen, H. Rhodius-Meester, M. Baroni, E. Lemstra, J. Bremer, A. Remes, T. Urhemaa, A. Tolonen, T. Tong, R. Guerrero, D. Rueckert, G. Waldemar, H. Soininen, P. Mecocci, W. van der Flier, J. Lötjönen and S. Hasselbalch. Computer assisted differential diagnosis of dementia disorders: The PredictND validation study. 27th Alzheimer Europe Conference, October 2-4, Berlin, Germany, 2017, accepted.

5. H. Rhodius-Meester, H. Liedes, T. Koene, A. Lemstra, C. Teunissen, F. Barkhof, P. Scheltens, M. van Gils, J. Lötjönen and W. van der Flier. AD related determinants, not co-morbidity, are associated with mortality in young AD patients. 27th Alzheimer Europe Conference, October 2-4, Berlin, Germany, 2017, accepted.

6. T. Paajanen, S. Mahdiani, M. Bruun, M. Baroni, H. Rhodius-Meester, A. Lemstra, S-K. Herukka, M. Pikkarainen, T. Hänninen, T. Ngandu, M. Kivipelto, M. van Gils, S. Hasselbalch, P. Mecocci, W. van der Flier, A. Remes, H. Soininen and J. Lötjönen. Detecting cognitive disorders using Muistikko web-based cognitive test battery – Validation in three cohorts. Alzheimer’s assocication international conference, AAIC-17, July 16-20, London, UK, abstract 19005, 2017.

7. J. Lötjönen, J. Koikkalainen, H. Rhodius-Meester, W. van der Flier, P. Scheltens, F. Barkhof and T. Erkinjuntti. Computed ratings scales for cognitive disorders from MRI. submitted to Alzheimer’s assocication international conference, AAIC-17, July 16-20, London, UK, abstract 18926, 2017.

8. M. Bruun, L. Gjerum, K. Frederiksen, H. Rhodius-Meester, M. Baroni, E. Lemstra, J. Bremer, A. Remes, T. Urhemaa, A. Tolonen, T. Tong, R. Guerrero, D. Rueckert, G. Waldemar, H. Soininen, W. van der Flier, P. Mecocci, J. Lötjönen, S. Hasselbalch. Data-driven diagnosis of dementia disorders: The PredictND validation study. submitted to Alzheimer’s assocication international conference, AAIC-17, July 16-20, London, UK, abstract 20015, 2017.

9. H. Rhodius-Meester, H. Liedes, S. Wolfsgruber, N. Coll-Padros, J. Koikkalainen, J. Kornhuber, O. Peters, F. Jessen, L. Kleineidam, J. Molinuevo, L. Rami, C. Teunissen. F. Barkhof, S. Sikkes, L. Wesselman, R. Slot, P. Scheltens, B. Tijms, J. Lötjönen and W. van der Flier. Prognosis of clinical progression in subjective cognitive decline using a clinical decision support system. Alzheimer’s assocication international conference, AAIC-16, July 24-27, Toronto, Canada, abstract 15466, 2017.

10. A. Tolonen, H. Rhodius-Meester, M. Bruun, J. Koikkalainen, F. Barkhof, B. Tijms, A. Lemstra, C. Teunissen, T. Tong, R. Guerrero, A. Schuh, C. Ledig, M. Baroni, D. Rueckert, H. Soininen, A. Remes, G. Waldemar, S. Hasselbalch, P. Mecocci, W. van der Flier and J. Lötjönen. Towards data-driven medicine in differential diagnostics of neurodegenerative diseases. Alzheimer’s assocication international conference, AAIC-16, July 24-27, Toronto, Canada, abstract 10536, 2016.

11. H. Pölönen, J. Koikkalainen, A. Tolonen, H. Rhodius-Meester, B. Tijms, A. Lemstra, F. Barkhof, T. Koene, C. Teunissen, D. Rueckert, H. Soininen, A. Remes, G. Waldemar, S. Hasselbalch, P. Mecocci, W. van der Flier and J. Lötjönen. Cost-efficient differential diagnostics of neurodegenerative diseases using a stratified approach. Alzheimer’s assocication international conference, AAIC-16, July 24-27, Toronto, Canada, abstract 10441, 2016.

12. A. Tolonen, H. Rhodius-Meester, M. Bruun, M. Baroni, J. Koikkalainen, F. Barkhof, B. Tijms, A. Lemstra, T. Tong, R. Guerrero, A. Schuh, C. Ledig, D. Rueckert, H. Soininen, A. Remes, G. Waldemar, S. Hasselbalch, P. Mecocci, W. van der Flier and J. Lötjönen. Data-driven differential diagnostics of neurodegenerative diseases. 2nd Congress of the European Academy of Neurology, May 28-31, Copenhagen, Denmark, 2016.

13. H. Rhodius-Meester, J. Koikkalainen, J. Mattila, J. Lötjönen, C. Teunissen, F. Barkhof, T. Koene, AW. Lemstra, P. Scheltens and W. van der Flier. Assessing underlying Alzheimers’s disease pathology in MCI patients from the Amsterdam Dementia Cohort by use of the PredictAD software tool. Alzheimer’s assocication international conference, AAIC-15, July 18-23, Washington DC, USA, abstract 3037, 2015.

14. M. Bruun, K. Frederiksen, G. Waldemar, H. Soininen, W. van der Flier, P. Mecocci, H. Rhodius-Meester, S-K. Herukka, M. Baroni, A. Remes, T. Urhemaa, J. Mattila, J. Lötjönen and S. Hasselbalch. A prospective validation study of the PredictND tool – a diagnostic decision support tool: Rationale and design of the study. Alzheimer’s assocication international conference, AAIC-15, July 18-23, Washington DC, USA, abstract 3488, 2015.

15. A. Hall, J. Mattila, M. Muños-Ruiz, A. Luikku, T. Pekkala, J. Koikkalainen, A. Solomon, V. Leinonen, P. Hartikainen, J. Lötjönen, H. Soininen. Applying the disease state index in studies with neurodegenerative diseases. 7th Kuopio Alzheimer Symposium, June 11-13, Kuopio, Finland, p. 72, 2015.

16. J. Lötjönen. Decision making tools in memory disease, PredictND. 7th Kuopio Alzheimer Symposium, June 11-13, Kuopio, Finland, p. 32, 2015.

17. A. Hall, M. Muñoz-Ruiz, J. Mattila, J. Koikkalainen, M. Tsolaki, P. Mecocci, I. Kloszewska, B. Vellas, S. Lovestone, PJ. Visser, J. Lötjonen, H. Soininen, for ADNI, AddNeuroMed, DESCRIPA and Kuopio L-MCI. Combining cohorts of patients with mild cognitive impairment to predict progression to Alzheimer’s disease. The 12th international conference on Alzheimer’s and Parkinson’s Diseases AD/PD 2015, Nice, France.

18. A. Luikku, A. Hall, O. Nerg, A. Koivisto, A. Sutela, M. Kojoukhova, J. Mattila, J. Rummukainen, I. Alafuzoff, J. Jääskeläinen, H. Soininen and V. Leinonen. The Disease State Index in prediction of shunt surgery outcome in idiopathic normal-pressure hydrocephalus. Hydrocephalus 2014, Meeting of the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders, Bristol, UK.